Оригинален напис Епидемиолошки карактеристики, безбедност и ефикасност на медицинскиот канабис кај возрасните луѓе Ran Abusahiraa,1, Lihi Bar-LevSchleidera,b,1, Raphael Mechoulamc, Victor Novacka,* Информации за написот А П СТ Р А К Т Клучни зборови: Медицински канабис Медицинска марихуана Возрасни луѓе Многу стари Опиоиди   Вовед: Постои значаен раст во употребата на медицинскиот канабис во последниве години […]

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Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in cannabis ∆9-tetrahydrocannabinol (THC) produces the majority of its pharmacological effects through two cannabinoid receptors, termed CB1 and CB2. The discovery of these receptors as linked […]

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Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma D Vara,1 C Morell,1 N Rodríguez-Henche,1 and I Diaz-Laviada1,* Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Cannabinoids exert antiproliferative effects in a wide range of tumoral cells, including hepatocellular carcinoma (HCC) cells. In this study, we examined whether […]

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Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms Luciano De Petrocellis,1,* Alessia Ligresti,2,* Aniello Schiano Moriello,1 Mariagrazia Iappelli,1 Roberta Verde,2 Colin G Stott,3 Luigia Cristino,1 Pierangelo Orlando,4,* and Vincenzo Di Marzo2 Author information ► Article notes ► Copyright and License information ► See commentary “Towards the use of non-psychoactive cannabinoids for prostate cancer” on page 76. This article has been cited by other articles in PMC. Go to: […]

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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 R. G. Pertwee, A. C. Howlett, M. E. Abood, S. P. H. Alexander, V. Di Marzo, M. R. Elphick, P. J. Greasley, H. S. Hansen, G. Kunos, K. Mackie, R. Mechoulam, and R. A. Ross Author information ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: […]

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Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications Javier Fernández-Ruiz,1,2,3 María A. Moro,4,5 and José Martínez-Orgado6 Author information ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Cannabinoids form a singular family of plant-derived compounds (phytocannabinoids), endogenous signaling lipids (endocannabinoids), and synthetic derivatives with multiple biological effects and […]

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Immunoactive effects of cannabinoids: considerations for the therapeutic use of cannabinoid receptor agonists and antagonists William E. Greineisena,b and Helen Turner.a,c,d Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Int Immunopharmacol Abstract The active constituents of Cannabis sativa have been used for centuries as recreational drugs and medicinal agents. Today, marijuana is […]

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Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection Sandeep Vasant More and Dong-Kug Choi Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Parkinson’s disease (PD) is a slow insidious neurological disorder characterized by a loss of dopaminergic neurons in the midbrain. Although several recent preclinical advances […]

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Br J Pharmacol. 2008 Jan; 153(2): 199–215. Published online 2007 Sep 10. doi:  10.1038/sj.bjp.0707442 PMCID: PMC2219532 The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin R G Pertwee1,* Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Abstract Cannabis sativa is the source of a unique set of compounds known […]

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